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EGCG, being a polyphenolic compound, suffers from poor aqueous solubility and is further hindered by its large molecular size and hydrophilicity, which restrict its absorption

Data availability The authors declare that all data supporting the findings of this study are available within the article and its Supplementary Information Files, and from the corresponding author upon reasonable request

The ultimate goal is to pinpoint a specific group of GUSs with activities that cause the toxicities of certain drugs or xenobiotics and to then develop inhibitors that selectively target those GUSs