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Description

The deprotonated forms of Lys and Arg with lower pKbs are much stronger bases than the deprotonated form of His, so at physiological pH, they would always be protonated (unless their local environment lowers their pKa and pKb values)

V.KohtalaS.TheilmannW.JalkanenA

Barnes-Vlez et al., 2023)

Likewise, improved glucose homeostasis in chemically and diet-induced animal models of diabetes is apparent, though limited data are available in humans