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In this study, by detecting the ROS concentration in trophoblast cells co-cultured with the ferroptosis inducer erastin, ferroptosis inhibitor ferrostatin-1 (Fer-1), apoptosis inhibitor Z-VAD-FMK and necrosis inhibitor necrostatin-1 (Nec-1) and the concentrations of ferroptosis markers in the placental tissue of pregnant women with PE and pregnant rats, we confirmed that trophoblast cells are specifically sensitive to ferroptosis and that ferroptosis occurs in the pathological state of PE