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However, critical evaluation requires acknowledging limitations: many studies lack the sample sizes and rigorous controls standard for Western regulatory purposes, independent replication has been limited, and long-term safety data in large human cohorts is lacking

Increased detection of Barretts esophagus-associated neoplasia using wide-area trans -epithelial sampling: a multicenter, prospective, randomized trial

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Mechanistically, L2HG acts as a metabolic-epigenetic regulator that inhibits 2-oxoglutarate-dependent dioxygenases, induces histone hypermethylation, and remodels chromatin accessibility to activate an ATF3-dependent transcriptional program