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In vivo anti-aging effects of naringin, a bioflavonoid: insights from the budding yeast Saccharomyces cerevisiae as a model organism

Hyperkinetic disorders include tremor, dystonia, myoclonus, and chorea

In return, the liver modulates the intestinal microbiota by secreting BAs, immunoglobulin A, and antimicrobial molecules into the intestine 34

Consequently, even after oral administration of high doses, plasma and tissue concentrations of the native compound remain substantially below the levels required to elicit significant pharmacological effects within the central nervous system