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Description

After NLRP3 activation, ASC and pro-caspase-1 assemble the NLRP3 inflammasome, which mediates the self-cleavage of pro-caspase-1 and formation of the active caspase-1 p10/p20 tetramer

Mol Cell Endocrinol 460:246257

Bacterial infections (overwhelmingly staphylococcal) were the most common and manifested as folliculitis, erysipelas, cellulitis, and abscess formation