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A reduction in G i2 protein, but not G o and G s , expression has been described in cabergoline-resistant with respect to sensitive prolactinomas ( i13 proteins has been reported in GH-secreting tumors ( Alterations in SSTRs signal transduction might be the cause of typical octreotide-resistance observed in acromegalic patients bearing germline mutations in aryl hydrocarbon receptor interacting protein (AIP) gene ( i signaling ( Genetic analysis of AIP in 50 non-familial acromegalic patients resistant to treatment with SS analogs revealed a low, but non-negligible, prevalence of AIP germline mutations ( Fougner et al