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In the real world, the most immediate risk is often not the molecule it is the supply chain

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The study comparing a diet with high fat/high sucrose and high fat/high sucrose with cranberry extract revealed that polyphenols lowers total weight gain, visceral adipose tissue weight, hepatic triglyceride accumulation, and plasma cholesterol levels ( in vitro study has also demonstrated that the polyphenols contained in pomegranate extracts in combination with probiotics induces synergistic effects that substantially reduces the triglyceride levels and intracellular lipid increase (Sorrenti et al., 2019)