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The mechanism behind these reactions typically involves a localized inflammatory response

Much of the observed benefit in MIC programmes plausibly comes from the programme, not the vial

However, the hormonal optimization effects are not permanent without continued use

Local rashes most often come from three mechanisms: An immune response to the medication itself, sending histamine to the injection area Sensitivity to an inactive ingredient like a preservative or buffer in the formulation Mechanical trauma from the needle or a fast injection technique The immune explanation is straightforward: a neighborhood-level alarm that sends histamine and inflammatory signals, producing redness and itch