influences glutathione s-transferase activity The triple role of S-transferases in mammalian male fertility | Cellular and Molecular Life Sciences Frontiers | Glutathione S-Transferase Enzymes

In the young lens, high GSH levels are maintained by several different pathways including the direct uptake of GSH from the ocular humours, intracellular synthesis of GSH from cysteine, glutamate and glycine by the sequential actions of the enzymes glutamate cysteine ligase (GCL) and glutathione synthetase (GS), regeneration of GSH from oxidised GSH (GSSG) by GSH reductase (GR), and export and degradation of GSH into its precursor amino acids for re-uptake by the lens (7)

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Collectively, regardless of disease status, this cohort of children from a konzo-affected region show signs of protein malnourishment, harbor measures of mitochondrial distress, and deficiencies in a key sulfur-containing amino acid (Cystine)