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[6] The only notable exception is that biotin should not be used in anyone with a known hypersensitivity or allergy to biotin or any ingredients in the injection formulation (such as the diluent or preservatives), though such cases are exceedingly rare

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*Journal of Clinical Endocrinology & Metabolism*, 96(7), 1911-1930

The clinical data on AOD-9604 demonstrates remarkable hormonal stability, with no effects on cortisol, thyroid hormones, sex hormones, or the growth hormone/IGF-1 axis