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44 Subsequent work has definitively demonstrated a crucial role for c-Rel and RelA in mediating induction of the Th17 lineage transcription factor RORt and the generation of Th17 cells

NIK activation by TNFRs, such as CD40 and BAFF receptor (BAFFR), involves degradation of TRAF3, which causes liberation and stabilization of NIK, triggering the activation of downstream non-canonical NF-B pathway (Fig

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