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HDFA did not appear to have any effect on these biomarkers and these biomarkers were not examined in the mB12/LDFA study

Crosstalk through NLRP3 The NLRP3 inflammasome is a multi-protein complex that recognizes PAMPs or damage-related molecular patterns (DAMPs) and activates the protease caspase-1, leading to pyroptosis and the formation of mature IL-1 and IL-18 to mediate the inflammatory response (151)

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