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When the therapeutic treatment of T4 was administered after EAE symptoms onset instead of on the day of PLP immunization, functional outcomes revealed that this T4 treatment approach evoked significant functional benefit (Zhang et al., 2016a), and concurrently increased OLs in the demyelinating CNS

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It's a naturally occurring copper-binding peptide first isolated from human plasma in 1973 by biochemist Loren Pickart, who noticed that older liver tissue regenerated better when exposed to plasma from younger donors

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