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An early study reported that a low dose of the opioid agonist codeine impairs coding performance in medical troops tested at 2,000 feet (610 meters) altitude but improved performance when they performed this test at 15,000 feet (4,572 meters) elevation (Evans & Witt, 1966)

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TB-500 has been shown to improve left ventricular function in mice following myocardial infarction, providing compelling evidence that it is beneficial for tissue repair and may mediate cardioprotection