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Studies have shown that in mice with DSS-induced acute colitis, IDO1 expression and the Kyn/Trp ratio are significantly increased, whereas they decline during the chronic phase

the pi of one masking moiety may be in the range of 3 to 5, preferably 3.5 to 4.5, more preferably 3.9 to 4.5, while the pi of the other masking moiety is in the range of 5.0 to 7.0, preferably 5.5 to 6.0

As the target can be located in intracellular compartment of the brain parenchyma, the main determinant of successful application of the approach for delivery of drugs with the brain parenchymal intracellular targets is an improvement of unbound steady-state concentrations of released parent drug in intracellular compartment in comparison to parent drug dosing