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Particularly in conjunction with each other and at what times

Obesity contributes to all components of metabolic syndrome, especially in the presence of excess abdominal fat (Batsis, Nieto-Martinez, & Lopez-Jimenez, 2007)

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However, when emodin, rhein and to a lesser extent cis -stilbene, were used in combination with each topoisomerase II inhibitor, there was an antagonistic increase in ATP, an inhibition of apoptosis and no cell-cycle arrest