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Commonly suggested biomedical hypotheses to explain PAIS (such as in long COVID/PASC, ME/CFS) are chronic stimulation of the immune system by a persistent infection or persistent unviable pathogen structures

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doi: 10.1016/j.numecd.2010.05.003 12 CaoH.LiuX.AnY.ZhouG.LiuY.XuM.et al

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However, no significant ROS accumulation (neither mitochondrial SOX nor cellular ROS) was detected upon BSO treatment ( Supplemental Figure 2B )

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Dietary implications on TMAO are clear

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