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Endoplasmic reticulum stress related genome-wide Mendelian randomization identifies therapeutic genes for ulcerative colitis and Crohns disease

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The mutation in ALDH4A1 leads to the accumulation of pyrroline-5-carboxylate (P5C) in the mitochondria, which can react with PLP to cause PLP deficiency in the brain and can also be converted to proline, resulting in elevated plasma proline levels (Fig

Among these, BPC-157 (Body Protection Compound-157), a synthetic peptide derived from a protective protein found in gastric juice, has garnered significant attention for its remarkable regenerative and anti-inflammatory properties