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Mitochondrial inner membrane permeabilisation enables mt DNA release during apoptosis

PloS One 5(4): e10423-e10423

Lancet 399 , 13131321 (2022)

This DHFR-independent pathway replenishes the intracellular THF pool, sustaining 1 C metabolism for nucleotide synthesis and methylation reactions, thereby maintaining cancer cell proliferation and contributing to acquired resistance to DHFR-targeted antifolate therapies [157, 158]