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The higher the mitochondria energy output the better physiological health of the individual

364,365 A recent study suggested that the E3 ligase TRIM22 functions as a tumor suppressor in breast cancer by degrading CCS (copper chaperone of SOD1), thereby reducing the copper supply to SOD1, impairing SOD1 activity, increasing ROS levels, and suppressing STAT3-dependent oncogenic pathways

189 The MBD protein family includes multiple members, such as MBD2 and MBD3, which affect gene expression by regulating DNA methylation and histone modifications to, thereby participating in the formation and progression of tumors