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doi: 10.1016/j.neubiorev.2015.07.015 [DOI] [PubMed] [Google Scholar] 419

As expected, in ligature induced experimental periodontitis, a considerable increase in vascular permeability in the gingival tissue was detected

Interestingly, RXR, which is a unique nuclear receptor of the RXR subfamily, was predicted to be a target of sulindac by the SEA database, and accumulating evidence indicates that RXR also has extranuclear functions 66,67,68