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When tissues sustain damage, GHK-Cu is released from extracellular matrix proteins including SPARC and collagen, functioning as a matrikine, a signal molecule that activates repair mechanisms

This is the amplification of pain transmission along the entire pain neuraxis, from peripheral nociceptors to the upper CNS regions that form the pain matrix and encode the perceptive, cognitive, and emotional aspects of pain [164]

Recent investigations (Kwon et al.) have identified AOD 9604 as a chondroprotective agent

Maintaining protein intake of 0.8-1.0g per pound body weight and continuing resistance training helps preserve muscle mass during treatment