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We continue to believe, as we did when this measure was adopted in the Hospital OQR Program measure set, there is evidence that excessive radiation leads to harm, [336] and evidence that radiation doses could be lowered in many patients' situations without deteriorating image diagnostic utility

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Intrinsic (mitochondrial) pathways are also activated, with pro-apoptotic Bcl-2 family members (Bid, Bak, Bax) promoting mitochondrial outer membrane permeabilization, cytochrome C release, and apoptosome formation (cytochrome C + APAF-1 + procaspase-9)