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Similarly, negatively charged memantine-loaded PEG-PLGA nanoparticles (zeta potential 22.4 mV) have shown excellent brain delivery, achieving sustained drug release following oral administration in APPswe/PS1dE9 (APP/PS1) and C57BL/6 mice (Snchez-Lpez et al., 2018)

Pulmonary fibrosis studies using bleomycin-induced injury show reduced inflammatory cell infiltration and interstitial thickness at doses of 2.6-260 g/mL/day