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In most cases what they experience instead is a weight-loss plateau

Dosage Precautions Treatment with this drug should be administered with caution if the animal has chronic renal failure

Conventional DMARDs (e.g., methotrexate, leflunomide, sulfasalazine): Methotrexate slows joint damage and suppresses inflammation but causes hepatic toxicity and bone marrow suppression, leading to 30% treatment discontinuation within one year (8)