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Nat Rev Immunol (2026)

Chemical Identity Property Value Full Name Tesamorelin acetate Type GHRH analog (Growth Hormone-Releasing Hormone) Amino Acids 44 amino acids Molecular Weight ~5135 Da Modification Trans-3-hexenoic acid addition at N-terminus Brand Name Egrifta (Theratechnologies Inc.) CAS Number 218949-48-5 Mechanism of Action Tesamorelin works by binding to GHRH receptors on somatotroph cells in the anterior pituitary gland

J Biol Chem (2008) 283(9):525866.10.1074/jbc.M707125200 92 WernigGGonnevilleJRCrowleyBJRodriguesMSReddyMMHudonHEet alThe Jak2V617F oncogene associated with myeloproliferative diseases requires a functional FERM domain for transformation and for expression of the Myc and Pim proto-oncogenes