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Long COVID-associated brain fog induces structural changes in the brain To explore if there were structural brain changes accompanying increased BBB permeability in our cohorts, we conducted volume and thickness measurements on recovered, long COVID and 60 age-matched healthy controls from the publicly available IXI dataset (Supplementary Table 2) and examined global brain volume (GBV), cerebrospinal fluid (CSF) volume and the right and left volumes of the cerebral and cerebellar white matter (WM) and gray matter (GM), and the brainstem, hippocampus and amygdala