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Moreover, 50 or 100 mg/kg of luteolin has been found to markedly attenuate DSS-induced murine colitis symptoms compared with a DSS group, primarily by inhibiting JNK1/2, phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) signaling, NF-B and STAT3 pathways to exert anti-inflammatory, anti-apoptotic and anti-autophagic effects for colonic homeostasis restoration (68)

Moreover, PGC-1 overexpression induces higher hepatotoxicity also exacerbating the oxidative stress that finally leads to liver failure and mice death

Not recommended for facial use