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Copper has a complex role in oxidative biology participating in both prooxidant chemistry (where free or weakly bound copper can catalyze damaging reactive-oxygen-species generation) and antioxidant chemistry (as the cofactor of Cu/Zn superoxide dismutase)

However, despite these successes, there is an urgent need for a better understanding of the role of Gln in tumor metabolism and therapy resistance depending on the genetic profile of cancer cells and the dynamically changing tumor microenvironment