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characteristic of intrahepatic cholestasis of pregnancy Hepatomegaly / splenomegaly hepatosplenomegaly suggests hemolytic anemia or portal hypertension Neonatal-specific: poor feeding, lethargy, high-pitched cry, hypotonia early warning signs of acute bilirubin encephalopathy

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Finally, emphasis was given to the possible integration of the nanoparticles with other emerging technologies for the symptomatic management of PD