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24 The classic LCT KD is the most traditional type of the KD, is widely used in the clinical setting, and incorporates a 4:1 ratio of fat (in grams) to protein plus carbohydrate (in grams)

Glutamate receptors are widely present in immune cells such as T cells, B cells, DCs, and macrophages, making it possible for glutamate to play a role in both innate and adaptive immune systems (60, 61)

Nest, we cocultured M1 macrophages (LPS-stimulated, CD68 + CCR7 + CD206 ) or M2 macrophages (IL-4stimulated, CD68 + CCR7 CD206 + ) with purified primary LR-MSCs in a transwell system (Fig