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381 Valproic acid (VPA) suppresses autophagy, while promoting apoptosis in myeloid leukemia, 349 whereas apicidin induces both autophagy and apoptosis in OSCC by upregulating LC3-II and ATG5

Notes: Before first use, perform a patch test to rule out skin reactions

the predicted binding mode of 1j indicates the C5-amino substituent forms hydrogen bonding interaction with the carboxylic backbone of the Ser201 residue and a hydrophobic bonding with the Ser213 residue unlike the NCA amide group that is in hydrogen bonding distance from with the NNMT Ser213 residue

A likely possibility is that homoglutathione replaces glutathione as the dominant cellular redox-buffer in tissues associated with nitrogen fixation, as homoglutathione is required for proper development of nodules (Frendo et al., 2005)