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Description

Pharmacological characterisation of novel adenosine A 3 receptor antagonists

Miyagi SJ, Brown IW, Chock JM, Collier AC

We have hypothesized that a hybrid ester prodrug (see Figure 1) containing the QM generating moiety that is selectively hydrolyzed and activated by oxidized protein hydrolase (OPH) will deplete intracellular GSH (see Figure 2) and promote oxidative stress induced apoptosis in cancer cells by a mechanism similar to that of NO-ASA, i.e., release of a QM depleting intermediate [23]