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This strategy is expected to not only elucidate the molecular basis of HBOs improvement of high-altitude cerebral injury and clarify the role of stress parameters in the formation of efficacy, but also provide mechanistic basis and biomarker clues for the development of dose-stress-time optimization and higher quality translational and clinical studies

For instance, baicalein has been shown to effectively suppress ALOX-15 in HT22 cells and ACSL4-mediated ferroptosis in myocardial I/R rats, thereby significantly attenuating myocardial I/R injury [143, 144]

Members of the AK1C family, belonging to AKRs superfamily, have been suggested to play a pivotal role in maintaining steroid homeostasis 29

Goats in the HS groups experienced moderate to severe HS