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Wilbourn, International Agency for Research on Cancer, Lyons, France ------------------------------------------------------------------- a IPCS Consultant

The findings from current study align with previous proteomic studies of liver organoids, which have demonstrated their capacity to recapitulate liver-specific phenotypes

In many locations, the relationship between temperatures and risk of death is steeper on the warm side of the optimal temperature than on the cold side (referred to as J-shaped exposure-response functions), so it can be the case that warming would increase heat-related deaths more than it would decrease cold-related deaths even as cold deaths remain higher than heat deaths

The clinical rationale rests on the age trajectory of the axis