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These are seen in several other types of EDS as well, typically in classical EDS

According to FDA prescribing information, injection site reactions vary by dose and formulation, with clinical trials showing rates of approximately 1.7-5.2% for Mounjaro and 2.4-5.3% for Zepbound, depending on the dose used

Consistently with a role in fibroblast activation, an amelioration of tissue fibrosis was observed in TLR4 knockout in murine models of systemic sclerosis [131]