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Taken together, these results demonstrate that the Nrf2 gene is directly regulated by the core clock via conserved E-box element in its promoter and also that Nrf2 transcriptionally regulates BMAL1 and CRY2 expression, thereby establishing a feedback loop and providing a possible molecular mechanism by which oxidative signals might input into the circadian clock

Aliotta PJ, Alvero R

47,53-55 These proteins control a transcription-translation feedback loop that is the core component of the circadian clock (Fig