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A detoxification gene linked to the secretion tag of our construct would theoretically allow the enzyme to be produced and transported out of the cell into the bee gut, which is the principal location of bee insecticide metabolism [1]

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Mechanism of action Calcium antagonists inhibit the influx of calcium ions through slow channels in vascular smooth muscle and cause relaxation of both coronary and peripheral arteries

Targeted therapy and ototoxicity Newer therapies aimed at specific cancer types, such as tyrosine kinase inhibitors (TKIs), have been associated with vestibular dysfunction, though their precise ototoxic mechanisms remain under investigation