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Importantly, the pivotal cardiovascular and obesity outcome trials of GLP-1RAs, including the Semaglutide Unabated Sustainability in Treatment of Type 2 Diabetes (SUSTAIN), Semaglutide Treatment Effect in People with obesity (STEP), and SURPASS (tirzepatide) programs, did not report clinically meaningful increases in AITD or sustained thyroid dysfunction [7,8,30]

Researchers became interested in combining these peptides when early studies revealed their complementary pharmacokinetics: Ipamorelin peptide provides an immediate GH pulse (peaking within 40 minutes), while CJC-1295 sustains release over several hours

Multislice CT enteroclysis in the diagnosis of bowel endometriosis