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Research suggests that calcium deficiency may be a common concern for women with PCOS, although the exact relationship between calcium status and insulin resistance remains uncertain [141]

Sp1 and Sp3 transcription factors mediate malondialdehyde-induced collagen alpha 1(I) gene expression in cultured hepatic stellate cells

Experimental evidence indicates that oxidative stress can reduce antioxidants such as superoxide dismutase (SOD), glutathione peroxidase (GPx), and increase the level of malondialdehyde (MDA), resulting in disruption of lipid membranes, cellular proteins and DNA ( Hmox1 gene) is an essential antioxidant signaling pathway that protects against inflammation, apoptosis, and oxidative stress (Upadhayay and Mehan, 2021)

Vt SR, Constantin V, Serban MN et al (2016) The efficacy and safety of hepatic arterial infusion of oxaliplatin plus intravenous irinotecan, leucovorin and fluorouracil in colorectal cancer with inoperable hepatic metastasis