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Targeting Misfolded p53 and p53 Aggregation to Overcome Resistance to Apoptosis in Acute Myeloid Leukemia

(2020) showed that loss of SQOR in a mouse model of ulcerative colitis (UC) disrupts the intestinal epithelial barrier integrity and causes severe mitochondrial dysfunction

doi: 10.1101/cshperspect.a020412 311 WatkinsSRobelSKimbroughIFRobertSMEllis-DaviesGSontheimerH

Although immune potentiators show promise, particularly in tumor immunotherapy, they are often associated with toxicity and systemic side effects due to rapid diffusion into circulation (Abhyankar et al