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demonstrated that OS triggers DNA methyltransferase 1 (DNMT1)-dependent methylation of ALDH promoters, resulting in decreased ALDH expression and -alanine synthesis and reducing carnosine availability

Other possible sources for MG formation include the auto-oxidation of surgars, as well as the metabolism of acetone and aminoacetone ( FIGURE 1 MG Detoxification in Plants via Glyoxalase and Other Metabolic Pathways Methylglyoxal detoxification involves the conversion of MG to less toxic molecules, thus limiting its detrimental effects

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These molecules aid clearance of the damaged tissue but can also induce harm to healthy surrounding tissue ( As shown, muscle injury evoked by exercise is a complex response including multiple cells and multiple molecules (Figure 1)