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After 2 weeks, the exercise groups ran on a treadmill at 25 m/min for 30 min

doi: 10.18632/oncotarget.17589 83 ChenYHMcGowanLDCiminoPJDahiyaSLeonardJRLeeDYet al

MansonJEChlebowskiRTStefanickMLAragakiAKRossouwJEPrenticeRLet al

NNMT inhibition increases cellular concentrations of both substrates that the enzyme would otherwise consume: SAM (the universal methyl donor) and nicotinamide (the NAD + salvage precursor)