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Description

Nonalcoholic fatty liver disease in adolescents receiving valproic acid

Although we were able to examine mutations of the MID domain, as described below, results of PAZ mutations were difficult to interpret in this assay, presumably because the mutations also caused defects in PAZmiRNA association that impaired complex formation or stability in cells, which reduced co-IP of not only miR-7 but also the control miRNAsregardless of the presence of ZSWIM8 (Extended Data Fig