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In Phase 3 trials, retatrutide 12 mg achieved 28.7% body weight reduction at 68 weeks, while mazdutide 9 mg achieved 20.1% at 60 weeks

The ferroptosis suppressor protein 1(FSP1)/coenzyme Q 10 system constitutes a primary parallel defense: localized at the plasma membrane, FSP1 functions as a CoQ oxidoreductase that utilizes NAD(P)H to reduce CoQ to ubiquinol (CoQH 2 ), which acts as a lipophilic radical-trapping antioxidant to inhibit ferroptosis ( Two additional pathways provide further defense: GTP cyclohydrolase 1 (GCH1) protects against lipid peroxidation through the synthesis of tetrahydrobiopterin, while DHODH sustains the mitochondrial CoQH 2 antioxidant pool ( 2.3 Regulation of iron metabolismthe death catalyst As an iron-dependent form of cell death, ferroptosis is characterized by an expanded labile iron pool (LIP), primarily comprising Fe +