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Obsessivecompulsive disorder Similarities exist among brain regions implicated in addiction and obsessivecompulsive disorder (OCD), including the nucleus accumbens and anterior cingulate cortex.54,55 There have been reports of oxidative stress in populations with OCD, including increased lipid peroxidation;5659 decreased vitamin E,58 catalase, GPx and selenium;59 increased superoxide dismutase;59 and changes in overall oxidative status.60 Some of these alterations have been linked to symptom severity.57,59 Standard first-line therapies for OCD generally include a combination of serotonin reuptake inhibitors (SRIs) and psychotherapy

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Specific case reports have indicated that acneiform eruption or periungual inflammation due to EGFR inhibitors have been reduced by topical adapalene (18,19)