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Dysregulated Red Blood Cell ATP in Disease Settings ATP and Adenosine in Sickle Cell Disease Sickle RBCs are characterized by elevated indices of oxidative stress and depressed ATP (Sabina et al., 2009), as well as elevated 2,3-DPG

The point is to have a framework for which markers to assess when the clinical picture suggests early immune activation, rather than waiting for the picture to become undeniable