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Synthesis and Pharmacological Evaluation of Heterocyclic Carboxamides: Positive Allosteric Modulators of the M1 Muscarinic Acetylcholine Receptor with Weak Agonist Activity and Diverse Modulatory Profiles

Strikingly, mutations of various epigenetic regulators have been identified in about 50% of human cancers, and tumors without such mutations have expression changes coinciding with altered epigenetic activity [2]