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The study population characteristics were: median age of 64 years (range: 34 to 84), 49% age 65 years or older, 59% male, 94% White and 3% Asian, and 18% with history of brain metastases at baseline

Therefore, these findings further support the observation that low IGF-1 preferentially benefits females, and suggest that a potentially broad therapeutic window to target IGF-1R signaling may exist in females, with greater benefit possible by initiating at even younger ages than implemented in this study

The findings show that MOTS-c may serve as a VC inhibitor by activating the AMPK signalling pathway and inhibiting the AT-1 and ET-B receptors [79,82,83]

Lysosomes and various diseases A growing body of evidence indicates that the structural and functional stability of lysosomes are essential for maintaining cellular homeostasis 2,3